I try to sync my iPhone with my iTunes, everything appears to go normally, and when it's almost done, or maybe even done, I get an error saying that it can't sync and when I check my iPhone no new information was transferred.
*The error is apparently unknown, yet labeled (-53), and I couldn't find any information on it
I'm not an Ipod or even an Itunes user, so not familiar and possibly useless in helping you.
But here is the How-To: http://support.apple.com/kb/HT1386
It might be important for you to be sure to:
update the computer's OS before installing or syncing
Update JAVA JRE
Update Flash Player
Update .net Framework, particularly update to v 3.51 (from MS Updates)
That page is to help first time sync-ers not to troubleshoot issues with current ones so it didn't benefit me much. I'm not aware of how exactly to update the things that you mentioned though, unless I have to just manually search for them and download whatever they say is the newest version online
Uninstall all JAVA related items via Control Panel - Add/Remove
next:
Download and install the "offline" JRE 6 Update 16, here:
http://java.sun.com/javase/downloads/index.jsp
To see if you have already installed .net Framwork 3.51 updates
Open Control Panel - Add/Remove
Place a Checkmark/Tick at the top for "Show Updates
scroll the populated list.
there are (3) three hotfix/updates for 3.5 SP I (KB958484, KB 963797, and KB953595)
You should have them all installed.
If not, go to MS Updates and allow updates.
Note: There are "differences of opinion" regarding Internet Explorer 8.0.
I do not use it, and still use IE 7.0 because of compatibility issues with .gov and contracting sites that I frequent.
The choice is up to you and your usage. But I thought I'd best give you a heads-up in case IE 8.0 was listed as an update, so you could make an intentional choice.