Sorry you are having problems again. You reported in the other post that your system was running like "GOLD". So when did it start to slow down?
Have you scanned for malware? Since your system was cleaned last month, what are you (and all users of that PC) doing to prevent reinfection?
I recommend you run Disk Cleanup on the drives and run a scan with
Malwarebytes's Anti-Malware (MBAM).
We need some more information about your computer.
Make and model number of the motherboard, or computer if factory built.
Make and model of graphics card
Power supply make, model, or specifications
How many hard drives? How much free disk space on each?
What are your Virtual Memory (Page File) settings?
This "rumbling" sound - is it coming from inside the computer case, or the speakers? If the case, lay your hand on the case, can you feel the rumbling? Vibrations can only come from things with motors, either fans, or harddrives - which have two.
I recommend the interior of every computer be visually inspected, and cleaned if necessary, at least once a month. Shutdown Windows, power off AND UNPLUG the computer. Then pop open the side poke your nose inside - any burnt type smells? Look inside. If full of dust and dirt, it needs to be cleaned out (see
here for some cleaning tips). Touch bare metal of the case
before reaching inside to discharge any static in your body, then make sure all connectors are securely fastened. Give each fan a little flick to see if it moves freely. Note the position of all the fans, including in the PSU, under the graphics card (if present) and throughout the case. Note the locations of the hard drive(s).
If all appears fine, try to position cabling to minimize restricting front to back air flow, then check to make sure you did not loosen any connectors messing with the wires.
With the side panel still off, connect and start up the computer with you up close looking inside and and listening for the source of the rumble. If it appears to be a fan, touch bare metal again, then very carefully reach inside and momentarily touch the center hub of the fan. This will cause the speed to drop and change the pitch (or even stop- temporarily) the rumbling. 40mm chipset (if not passively cooled) and graphics card fans are frequent culprits.
If the fans appear good, then that points to the drives. There are two motors - one to spin the platters and one to move the arm that supports the read/write heads back and forth across the spinning platters. If the bearings in the drive motor are going, rumbling is the first sign, and seizure is looming. You need to back up your data now before your hard drive fails.
Read/Write "stepper motors" don't normally give any warnings of impending failure - they just stop. If the read/write head is banging back and forth from constant heavy drive activity causing rumbling noise, then we are back to malware or some other program running on your system.
Let us know what you discover.
Edit add: If you suspect the bearings in a hard drive, you can power down the computer again, then unplug the power connector from the drive in question and start the computer. It may not boot, you will know if the bearings are bad.