Hi Yes, there is no point in having them both running.
You say you are running a filesharing application, you will need all your good security products! and make sure you update them daily, as a minimum (hourly would be better!). Files sharing is notorious for introducing "undesirable elements" into computers as some/many of the files that are shared are "accompanied" by some pretty undesirable bits of code. These are often concealed or disguised to hide their darker side! If you are concerned about security this is one area that you really need to think hard about, and when you have done thinking....consider it all very carefully, before taking action.
Scan everything at least twice that you download, have a good sniff around it, be very wary and keep the URL of the malware removal forum handy if you really want to do this.!
Here's a link to a site that gives further information:
Good luck, I think maybe you are going to need it!