Device security and incompatible drivers

Neither MS nor the manufacturer has the drivers for these external drives, They are about 12 years old and I don't have the name only the serial #.
I updated SES and both WD Books. I also downloaded what I think was a legacy driver. Nothing worked and it prevents core isolation from working.
Is my best bet to transfer the material to new drives and get core isolation to work that way?

​Without these drives attached to the PC, core isolation still won't work and the message is these drivers are incompatible. So will I have to do a clean install to fix this issue once the external driver is an updated one? The issue is in the registry and I am not good at hacks there.

Device manager>view>hidden drives removed and core isolation could be enabled.

​I did do a clean installation after anyway. Too much diagnosing.