You can safely remove anything Disc Cleanup recommends removing or gives you the option to remove, including System Restore points (it won't remove your latest one, just all the others cluttering up your Hard Drive space). It's a good idea to use this windows utility regularly.
Looking at your latest Overdrive results, you do seem to have a Defrag. problem and a Memory utilization problem affecting your Laptop's performance.
This is a more powerful defrag. utility worth installing and regularly useing:
Auslogics Disk Defrag.(free Version) Use 'External Mirror 1' on this page:
http://www.softpedia...load-45027.html
I think you should also download WinPatrol 19.3.2010.0 (Free Version) from here:
http://www.winpatrol.com/download.html
This is a Program Guard but it has a nifty feature that lets you see your Start-up programs with the ability to easily disable/enable them from starting up with your PC. The programs will not be removed and nor will they be stopped from being used WHEN and ONLY if they need to run. We can then consider which startup programs can be safely disabled from starting up with your Laptop and unnecessarily hogging valuable memory space which is slowing it down.
Although managing your start-up list can be done in Windows, this utility is a much safer option.
I use the professional versions of both the above programs and they are safe, a small download and easy to use.
Did you follow Doug's steps regarding Skype, as I notice it is still showing up in your Overdrive test ?
Cheers,
Lee