The new very much improved RegDefend 2.0 has been released:

Changes since RegDefend v1.300
  • Redesigned the GUI, RegDefend now falls under the "Ghost Security Suite" product range
    -Easier to use due to unneeded complexity being removed
    -New custom flat look, which is maintained throughout interface
    -Designed for multiple security components (RegDefend being one)
    -Now includes an integrated updater
    -Color/Theme changes take place dynamically, no restart needed
    -New "Emerald Green" color theme added
    -Various statistics added
  • New RegDefend Alert/Log window
    -Removed "current live log" setting and simply integrated it into a date based filtering system
    -Viewing old logs is now as simple as choosing the date you want to investigate
    -Logging now incorporates a "smart disk usage system" , which means log sizes are now at least 1/50th the size as previous versions over the same period of time
    -Reduced information in the listview to reduce clutter
    -Now show full alert information when an item is clicked upon
  • Updated RegDefend alert/ask user window
    -Now show commandline of application
    -Can now KILL the process or the thread performing the registry operation. Should work regardless of any process protection you have, so be careful
    -Now show recommendations on what to do for each registry alert, along with other information
    -Improved layout and design to aid reading
  • New Registry rules editor
    -Totally redesigned the interface, allowing easier creation/modification of rules
    -Application only rules added, allowing people to define rulesets for untrusted/unknown programs. For example you can block a program which is run in a certain location (temporary files, internet cache, etc) from accessing the registry.
    -Application rules can be filtered using both the command line (useful for svchost.exe/rundll32.exe) and with wildcards
    -Application rules can now use special strings to select the Windows directory, program files directory, internet cache, etc
    -Collapsed all of the .ghst files into a simple rdconfig.bin
    -Group ordering added
    -Rule ordering added
    -Rules editor is no longer the main part of the progam, which hides unneeded complexity from users who use the supplied rules
    -Now allow modification of every string the user can enter into the editor
    -Adding multiple rules into the editor is now easier
    -Added importing of RegDefend v1.3/v2.0 rules into the editor
    -Added exporting of RegDefend v2.0 rules
    -Improved wildcard handling, no longer have to manually set whether you used wildcards or not
    -Groups and rules can now have descriptions attached to them, to allow people who have no idea about registry locations to hopefully understand them better
    -Added the ability to move rules between groups through a right click menu
  • New Ghost Security Suite driver
    -Incorporated RegDefend into a unified driver system
    -Added command line caching
    -Implemented Short File Name to Long File Name resolution
    -Implemented new rule reading system fixing a few issues whilst being faster
    -Added optimizations to rule list searching, can be up to 200% faster now than previous version
    -Added lots of speedups, with improved design and caches
More Info & Download: RegDefend 2.0