Extreme slowness

My wife's computer is extremely slow logging in, opening applications, and switching between applications. It runs fine in Safe Mode. I have run hijack this and the results are below:

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\csrss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\system32\svchost.exe
C:\Program Files\Windows Defender\MsMpEng.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\system32\spoolsv.exe
C:\Program Files\Common Files\Symantec Shared\ccEvtMgr.exe
C:\Program Files\Symantec\LiveUpdate\ALUSchedulerSvc.exe
C:\Program Files\Norton AntiVirus\navapsvc.exe
C:\Program Files\Norton AntiVirus\AdvTools\NPROTECT.EXE
C:\WINDOWS\system32\HPZipm12.exe
C:\Program Files\Spyware Doctor\sdhelp.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\alg.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\wuauclt.exe
C:\WINDOWS\Explorer.EXE
C:\WINDOWS\system32\hkcmd.exe
C:\Program Files\Java\jre1.5.0_11\bin\jusched.exe
C:\Program Files\Synaptics\SynTP\SynTPLpr.exe
C:\Program Files\Synaptics\SynTP\SynTPEnh.exe
C:\WINDOWS\system32\spool\drivers\w32x86\3\hpztsb12.exe
C:\Program Files\Common Files\Symantec Shared\ccApp.exe
C:\Program Files\Windows Defender\MSASCui.exe
C:\WINDOWS\system32\ctfmon.exe
C:\Program Files\Google\GoogleToolbarNotifier\1.2.1128.5462\GoogleToolbarNotifier.exe
C:\Program Files\Messenger\msmsgs.exe
C:\Program Files\HijackThis.exe

R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://go.microsoft.com/fwlink/?LinkId=69157
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://go.microsoft.com/fwlink/?LinkId=69157
O2 - BHO: Adobe PDF Reader Link Helper - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Adobe\Acrobat 7.0\ActiveX\AcroIEHelper.dll
O2 - BHO: PCTools Site Guard - {5C8B2A36-3DB1-42A4-A3CB-D426709BBFEB} - C:\PROGRA~1\SPYWAR~1\tools\iesdsg.dll
O2 - BHO: SSVHelper Class - {761497BB-D6F0-462C-B6EB-D4DAF1D92D43} - C:\Program Files\Java\jre1.5.0_11\bin\ssv.dll
O2 - BHO: Google Toolbar Helper - {AA58ED58-01DD-4d91-8333-CF10577473F7} - c:\program files\google\googletoolbar4.dll
O2 - BHO: PCTools Browser Monitor - {B56A7D7D-6927-48C8-A975-17DF180C71AC} - C:\PROGRA~1\SPYWAR~1\tools\iesdpb.dll
O2 - BHO: NAV Helper - {BDF3E430-B101-42AD-A544-FADC6B084872} - C:\Program Files\Norton AntiVirus\NavShExt.dll
O3 - Toolbar: Norton AntiVirus - {42CDD1BF-3FFB-4238-8AD1-7859DF00B1D6} - C:\Program Files\Norton AntiVirus\NavShExt.dll
O3 - Toolbar: &Google - {2318C2B1-4965-11d4-9B18-009027A5CD4F} - c:\program files\google\googletoolbar4.dll
O4 - HKLM\..\Run: [IgfxTray] C:\WINDOWS\system32\igfxtray.exe
O4 - HKLM\..\Run: [HotKeysCmds] C:\WINDOWS\system32\hkcmd.exe
O4 - HKLM\..\Run: [SunJavaUpdateSched] "C:\Program Files\Java\jre1.5.0_11\bin\jusched.exe"
O4 - HKLM\..\Run: [SynTPLpr] C:\Program Files\Synaptics\SynTP\SynTPLpr.exe
O4 - HKLM\..\Run: [SynTPEnh] C:\Program Files\Synaptics\SynTP\SynTPEnh.exe
O4 - HKLM\..\Run: [Cpqset] C:\Program Files\HPQ\Default Settings\cpqset.exe
O4 - HKLM\..\Run: [HPDJ Taskbar Utility] C:\WINDOWS\system32\spool\drivers\w32x86\3\hpztsb12.exe
O4 - HKLM\..\Run: [ccApp] "C:\Program Files\Common Files\Symantec Shared\ccApp.exe"
O4 - HKLM\..\Run: [ccRegVfy] "C:\Program Files\Common Files\Symantec Shared\ccRegVfy.exe"
O4 - HKLM\..\Run: [Advanced Tools Check] C:\PROGRA~1\NORTON~1\AdvTools\ADVCHK.EXE
O4 - HKLM\..\Run: [Symantec NetDriver Monitor] C:\PROGRA~1\SYMNET~1\SNDMon.exe /Consumer
O4 - HKLM\..\Run: [Windows Defender] "C:\Program Files\Windows Defender\MSASCui.exe" -hide
O4 - HKCU\..\Run: [ctfmon.exe] C:\WINDOWS\system32\ctfmon.exe
O4 - HKCU\..\Run: [swg] C:\Program Files\Google\GoogleToolbarNotifier\1.2.1128.5462\GoogleToolbarNotifier.exe
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~4\Office10\EXCEL.EXE/3000
O9 - Extra button: (no name) - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.5.0_11\bin\ssv.dll
O9 - Extra 'Tools' menuitem: Sun Java Console - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.5.0_11\bin\ssv.dll
O9 - Extra button: Spyware Doctor - {2D663D1A-8670-49D9-A1A5-4C56B4E14E84} - C:\PROGRA~1\SPYWAR~1\tools\iesdpb.dll
O9 - Extra button: (no name) - {e2e2dd38-d088-4134-82b7-f2ba38496583} - %windir%\Network Diagnostic\xpnetdiag.exe (file missing)
O9 - Extra 'Tools' menuitem: @xpsp3res.dll,-20001 - {e2e2dd38-d088-4134-82b7-f2ba38496583} - %windir%\Network Diagnostic\xpnetdiag.exe (file missing)
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O11 - Options group: [INTERNATIONAL] International*
O14 - IERESET.INF: START_PAGE_URL=http://ie.redirect.hp.com/svs/rdr?TYPE=3&tp=iehome&locale=EN_US&c=Q105&bd=presario&pf=laptop
O16 - DPF: {17492023-C23A-453E-A040-C7C580BBF700} (Windows Genuine Advantage Validation Tool) - http://go.microsoft.com/fwlink/?linkid=39204
O20 - Winlogon Notify: igfxcui - C:\WINDOWS\SYSTEM32\igfxsrvc.dll
O20 - Winlogon Notify: WgaLogon - C:\WINDOWS\SYSTEM32\WgaLogon.dll
O21 - SSODL: WPDShServiceObj - {AAA288BA-9A4C-45B0-95D7-94D524869DB5} - C:\WINDOWS\system32\WPDShServiceObj.dll
O23 - Service: Automatic LiveUpdate Scheduler - Symantec Corporation - C:\Program Files\Symantec\LiveUpdate\ALUSchedulerSvc.exe
O23 - Service: Symantec Event Manager (ccEvtMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccEvtMgr.exe
O23 - Service: Symantec Password Validation Service (ccPwdSvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccPwdSvc.exe
O23 - Service: Google Updater Service (gusvc) - Google - C:\Program Files\Google\Common\Google Updater\GoogleUpdaterService.exe
O23 - Service: HP WMI Interface (hpqwmi) - Hewlett-Packard Development Company, L.P. - C:\Program Files\HPQ\SHARED\HPQWMI.exe
O23 - Service: InstallDriver Table Manager (IDriverT) - Macrovision Corporation - C:\Program Files\Common Files\InstallShield\Driver\11\Intel 32\IDriverT.exe
O23 - Service: iPodService - Unknown owner - C:\Program Files\iPod\bin\iPodService.exe (file missing)
O23 - Service: LiveUpdate - Symantec Corporation - C:\PROGRA~1\Symantec\LIVEUP~1\LUCOMS~1.EXE
O23 - Service: MSCSPTISRV - Sony Corporation - C:\Program Files\Common Files\Sony Shared\AVLib\MSCSPTISRV.exe
O23 - Service: Norton AntiVirus Auto Protect Service (navapsvc) - Symantec Corporation - C:\Program Files\Norton AntiVirus\navapsvc.exe
O23 - Service: Norton Unerase Protection (NProtectService) - Symantec Corporation - C:\Program Files\Norton AntiVirus\AdvTools\NPROTECT.EXE
O23 - Service: PACSPTISVR - Sony Corporation - C:\Program Files\Common Files\Sony Shared\AVLib\PACSPTISVR.exe
O23 - Service: Pml Driver HPZ12 - HP - C:\WINDOWS\system32\HPZipm12.exe
O23 - Service: ScriptBlocking Service (SBService) - Symantec Corporation - C:\PROGRA~1\COMMON~1\SYMANT~1\SCRIPT~1\SBServ.exe
O23 - Service: PC Tools Spyware Doctor (SDhelper) - PC Tools Research Pty Ltd - C:\Program Files\Spyware Doctor\sdhelp.exe
O23 - Service: Symantec Network Drivers Service (SNDSrvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\SNDSrvc.exe
O23 - Service: SymWMI Service (SymWSC) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\Security Center\SymWSC.exe

My initial glance can't catch anything…

Can anyone help?

Sorry for the delay
If you still need help and haven't posted at another forum.

Run AVG Anti-Spyware (ewido). Then scan and save the log from the scan.
Instructions and download link can be found here.

Rescan with hijackthis and post a new log include the header, with the results from AVG .
Also please describe how your computer behaves at the moment.

I figured out the issue. I had attached a new HP multi-function device before I loaded the HP drivers and the windows drivers and HP driver were battling each other. I then had a hard drive failure. So I cured it by rebuilding. Luckily I had a backup (having just bought an external drive).

Glad to here you got it fixed.